How many gallons of gas can a 2000 ford E250 van tank hold?

The fuel tank capacity for a 2000 Ford E250 van varies depending on the configuration (engine, body style, etc.). There's no single answer. It could range from approximately 20 to 30 gallons. To know for certain, you'd need to check the owner's manual for that specific van or look at the sticker inside the fuel filler door.