* Torque Capacity Mismatch: The Turbo 400 is a heavy-duty transmission designed for high-torque V8 engines. The 4.3L V6, while a robust engine, produces significantly less torque. Using a Turbo 400 would be overkill and inefficient. The transmission's internals might not be properly stressed, leading to premature wear.
* Gear Ratios: The Turbo 400's gear ratios are geared toward higher torque and lower RPM operation, ideal for big V8s. These ratios wouldn't be optimal for a V6, potentially resulting in poor fuel economy and sluggish acceleration.
* Size and Weight: The Turbo 400 is a physically large and heavy transmission. Fitting it into a vehicle originally designed for a smaller transmission could present significant challenges, potentially requiring modifications to the chassis and drivetrain.
* Cost and Complexity: Adapting a Turbo 400 to a 4.3L V6 would be a significant undertaking, requiring custom adapters, modifications, and potentially a custom driveshaft. The cost and complexity far outweigh the benefits.
In short, while it might be *possible* with extensive modifications, it's not practical or recommended. The 4.3L V6 is better suited to a transmission designed for its torque output and intended application, such as a 700R4, 4L60E, or similar.