* Engine Bay Space: While a big block *can* fit, it's a tight squeeze. You'll likely need to modify or replace the firewall, possibly the inner fenders, and potentially even the frame horns depending on the specific headers and accessories used.
* Transmission: You'll need to ensure your automatic transmission is compatible with the big block. The bellhousing bolt pattern is different from small-block Chevys. You'll likely need a big-block specific transmission and possibly a custom driveshaft.
* Motor Mounts: You'll need motor mounts designed for a big-block Chevy in a C10. Stock mounts won't work.
* Exhaust: Finding headers that fit a big-block in a C10 is challenging. Custom headers are often necessary.
* Steering: The engine may interfere with steering components, requiring modifications or different steering linkage.
* Cooling System: A big-block generates more heat than a smaller engine, and the stock C10 cooling system may be insufficient. Upgrades might be necessary.
In short, while it's *possible*, it's a major undertaking and not a simple bolt-in swap. It's a project best undertaken by someone with significant experience in engine swaps and fabrication. Expect to spend considerable time and money.