To find out definitively:
* Visually inspect the speakers: Remove the speaker grills (usually just pops off) and measure the diameter of the speaker. This is the most reliable method.
* Consult a repair manual: A repair manual specific to your 2001 GMC Sierra 1500 will list the speaker sizes. You can find these online or at auto parts stores.
* Check online forums: Search online forums dedicated to GMC Sierras or car audio. Someone may have already documented the speaker sizes for your specific model.
Don't rely on generic information; the sizes can vary quite a bit even within the same year and model.