* Engine Mounts: The 1968 327 will require custom engine mounts. The S-10's frame and engine bay are designed for much later small-block Chevy engines, and the older 327's mounting points won't align.
* Transmission: You'll need a compatible transmission and bellhousing. The transmission from the '68 Camaro likely won't bolt directly to the 327. You'll need to source a transmission appropriate for the S-10 and adapt it to the engine. Consider the space constraints of the S-10; a large transmission may require more modifications.
* Exhaust System: A completely custom exhaust system will be necessary. The S-10's exhaust routing and manifolds won't work with the older 327.
* Wiring Harness: The 1968 wiring harness will be entirely incompatible with the 1995 S-10's electrical system. You will need to either extensively modify the older harness or fabricate a new one, potentially including a custom engine management system (e.g., a standalone EFI system).
* Cooling System: The S-10's cooling system may or may not be adequate. You might need to upgrade the radiator and cooling system components to handle the 327's thermal output.
* Driveshaft: You'll likely need a custom driveshaft length to account for the different engine placement and transmission.
* Firewall Modifications: There's a good chance the engine might interfere with the firewall, requiring modifications to fit.
In short, while feasible, this swap is a major project requiring significant mechanical skills, welding expertise, fabrication abilities, and a good understanding of automotive electrical systems. It's not a weekend project and will be considerably more complex and expensive than swapping in a more modern small-block Chevy engine designed for later S-10s. You'll likely need to consult with experienced mechanics or hot-rodders to complete the job successfully.