To be certain, you should:
1. Consult your owner's manual: This is the best resource, as it will show you a diagram of your specific fuse box and relay locations.
2. Look for labels: The fuse box cover usually has a diagram showing the location of relays and fuses. Look for labels indicating "starter" or a similar designation.
3. Check online forums: Search online forums specific to Ford E250s from 2000, and look for pictures or discussions about starter relay location. Be sure to specify your engine type (e.g., 4.6L V8, 5.4L V8, 7.3L Diesel) for the most accurate results.
Caution: Always disconnect the negative battery terminal before working with electrical components in your vehicle.