On a 2000 Ford E-150 van, the radiator cap is typically located on the top of the radiator, towards the front of the engine compartment. However,
it's crucial to locate it visually rather than relying solely on a generalized description. The exact position can vary slightly depending on the engine and any modifications.
Look for a pressure cap on a large, typically black, plastic or metal container near the front of the engine. It will be somewhat round and likely have a warning about pressure. Be careful when touching it as it may be hot, especially when the engine is running or recently shut off.