Will a steering column out of 93 Chevy s10 fit into 88 2500 pickup?

No, a steering column from a 1993 Chevy S10 will almost certainly not fit a 1988 Chevy 2500 pickup. While both are GM trucks, there are significant differences in size, body style, and steering system components between a compact S10 and a full-size 2500. The mounting points, shaft length, and even the steering wheel connections are likely incompatible.