The EPA estimates for a 2001 Chevrolet S10 4x4 LS with the 4.3L V6 engine are approximately
15 mpg city / 19 mpg highway. Keep in mind that actual mileage will vary depending on driving conditions, maintenance, and driving style.
The fuel tank size is typically 18 gallons. However, it's always best to check your owner's manual for the exact specifications for your particular vehicle as there might be slight variations.
