* Engine: The F-250 came with a variety of engines in 2001 (V8s and a V10). A smaller V8 will get better gas mileage than a larger V8 or the V10.
* Transmission: Automatic or manual transmissions will affect fuel economy.
* Drivetrain: 4x2 (two-wheel drive) models will generally get better gas mileage than 4x4 (four-wheel drive) models.
* Payload and Towing: Hauling heavy loads or towing a trailer will drastically reduce fuel economy.
* Driving habits: Aggressive driving will lower fuel economy.
* Vehicle condition: Proper maintenance contributes to better fuel efficiency.
Therefore, there's no single answer. You'll find a range of EPA estimates from various sources, but these are often optimistic under real-world conditions. Expect 8-15 MPG as a rough range, with the lower end being more likely for heavier use and larger engines, and the higher end more achievable with lighter loads and a smaller engine in ideal conditions.
To get a more accurate estimate for a *specific* 2001 Ford F-250, you'd need to know the engine size and drivetrain configuration. You could then try searching online for EPA fuel economy estimates for that exact model.
