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Where is the thermostat located on a 2000 Chevy S-10 4.3L V6?

The thermostat on a 2000 Chevy S-10 with a 4.3L V6 is located at the very back of the engine, on the passenger side. It's often tucked in a somewhat difficult-to-reach spot, near the firewall. You'll likely need to remove some components to access it easily, such as the upper radiator hose and possibly some other hoses or parts in that area.