Will a Honda 250 Big red 3 wheeler rear end fit on 300?

No, a Honda 250 Big Red 3-wheeler rear end will not fit on a 300. The 250 and 300 models have different rear axle widths, and the mounting points for the rear end are also different. Additionally, the 300 has a larger engine and transmission, so the rear end from the 250 would not be able to handle the increased power and torque.