How much does it cost in tolls to travel from Detroit South Carolina if you are driving an 18 wheeler?

It is not possible to drive an 18 wheeler from Detroit to South Carolina without paying any tolls. The total cost of tolls will vary depending on the specific route taken, but it will typically be around $250. Some of the major toll roads that you will likely encounter include the Ohio Turnpike, the Pennsylvania Turnpike, and the Interstate 95 Toll Road.