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How many Miles per gallon 6-cylinder s10 pickup?

The fuel economy of a 6-cylinder S10 pickup truck varies significantly depending on the year of manufacture, engine size (even within the "6-cylinder" category), transmission type (automatic or manual), vehicle condition, and driving habits. There's no single answer.

You'll find a range of 15 to 22 MPG (miles per gallon) in combined city and highway driving is a reasonable estimate for many 6-cylinder S10s, but some might be higher or lower. To get a precise figure, you need to specify the exact year and model of the truck. The best source for the fuel economy would be the original owner's manual or the EPA fuel economy estimates for that specific year and model.