* Transmission: Automatic or manual transmission will impact fuel economy.
* Cab style: Regular cab, SuperCab, or Crew Cab will affect weight and thus mileage.
* Drive type: 2WD or 4WD. 4WD will generally get lower gas mileage.
* Driving conditions: City driving will yield lower MPG than highway driving. Terrain and driving style also play a role.
* Vehicle condition: Proper maintenance (including tire inflation) directly impacts fuel efficiency.
Considering these variables, it's impossible to give a single definitive answer. However, you can expect a range of 13-17 MPG combined (city and highway). You might see slightly higher highway mileage and considerably lower city mileage.
To find a more precise estimate for a *specific* 2000 Ford F-150 4.6L, you should consult the original owner's manual or look up fuel economy figures from sources like the EPA's fueleconomy.gov website (though data for older vehicles may be limited).
