If you're talking about the timing chain guides: These are absolutely critical. The timing chain guides keep the timing chain properly aligned. If the guides wear out or break, the timing chain can jump or break, leading to catastrophic engine damage – bent valves at minimum, a completely ruined engine at worst. This is a very expensive repair. Ignoring worn guides is extremely risky.
If you're thinking of a different kind of chain guide (e.g., on a bicycle or other mechanical device, or perhaps a misinterpretation): Please clarify.
In short, if you're concerned about the condition of a chain guide in a 2003 2.2L 4-cylinder engine, and you suspect it's related to the timing chain, it's crucial to have a mechanic inspect it immediately. Ignoring potential problems here can be very costly.