* Severe imbalance: The engine would vibrate violently and potentially damage itself. The rotational forces and inertia would be significantly uneven.
* Uneven power delivery: Power output would be dramatically reduced and jerky.
* Potential damage: The remaining cylinders would be overloaded, increasing wear and tear and potentially leading to catastrophic failure.
* Misfires and stalling: The engine management system would likely detect misfires and attempt to compensate, potentially stalling the engine.
While you could *temporarily* run a six-cylinder engine on four cylinders by mechanically disabling two (for example, by removing spark plugs or disconnecting fuel injectors), this is extremely detrimental to the engine and is not recommended under any circumstances. It's much better to simply not run the engine if you suspect a problem with two of the cylinders.