While you *could* theoretically adapt it to various frames (e.g., from a newer F-150, F-250, etc.), it would involve:
* Significant frame modifications: The newer frames are much wider and longer, requiring extensive cutting, narrowing, and potentially adding sections.
* Custom suspension: You'd need to fabricate a whole new suspension system to connect the body to the newer frame.
* Custom engine mounts and drivetrain: The engine and transmission from a modern Ford won't simply bolt in.
* Body modifications: The 1950 body will likely require significant modifications to accommodate the wider frame and different suspension geometry.
It's a complex project best suited for experienced fabricators and custom builders. It's far from a simple swap. Consider researching frame swap projects for similar vintage trucks to get a better idea of the scale of work involved.