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What is the average gas mileage on a 2001 Ford F-150 with V6 engine?

The average gas mileage for a 2001 Ford F-150 with a V6 engine varies depending on several factors including driving conditions (city vs. highway), vehicle condition, and specific V6 engine (there were a couple of options that year).

However, a reasonable estimate for combined city and highway driving would be in the 15-18 MPG range. You might see slightly higher MPG on the highway and significantly lower in city driving. Keep in mind this is just an average, and your actual mileage may differ.

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