Where is the oil drain plug on a 2001 F150 2wd v6?

On a 2001 Ford F-150 2WD with a V6 engine, the oil drain plug is located on the bottom of the oil pan. The oil pan is the large, somewhat rectangular metal pan underneath the engine. The drain plug itself is usually a hexagonal bolt.

To be more precise, you'll find it towards the front of the oil pan, though the exact position might vary slightly depending on the specific engine (there were a few different V6 options that year). You'll need to get under the truck to see it. Be sure to use jack stands for safety and not just a jack.