* Engine: The E-350 is offered with a range of engines, from V6 to V8 gasoline engines and diesel options. Larger engines and those without fuel-saving technologies will get significantly worse gas mileage.
* Transmission: Automatic transmissions generally have slightly lower fuel economy than manuals (though manuals are rare in this class of vehicle).
* Payload and Towing: Carrying a heavy load or towing a trailer will dramatically reduce fuel economy.
* Driving style: Aggressive driving habits will lower MPG.
* Vehicle condition: Proper maintenance is crucial for optimal fuel efficiency.
* Year of manufacture: Newer models often incorporate technology improvements that enhance fuel economy.
Therefore, there's no single answer. You'll find a wide range of EPA estimates depending on the specific configuration. Expect generally low MPG figures, in the range of 10-18 MPG for gasoline engines and potentially slightly better for diesel options, but always significantly below the fuel economy of smaller vehicles. To find the exact MPG for a specific year and configuration, you should consult the EPA's FuelEconomy.gov website or the owner's manual for that particular vehicle.
