The oil drain plug on a 2005 Ford Escape V6 is located on the
bottom of the oil pan, which is situated
underneath the engine. You'll need to get under the vehicle to access it. It's typically a 13mm bolt (though always double-check with a wrench before you start to be certain), and it's usually near the front of the oil pan.
Important Note: Always consult your owner's manual for the precise location and any specific instructions or warnings before attempting any maintenance on your vehicle. The manual will have diagrams and further information.