* Input Shaft: The input shaft on the transmission from the 2.2L S10 will be sized for the smaller engine's torque. The 5.3L Tahoe's significantly higher torque output will likely overload and damage the smaller input shaft.
* Torque Converter: The torque converter from the S10 is matched to the 2.2L engine. It's not designed to handle the higher torque of the 5.3L and will likely slip or fail.
* Flexplate/Flywheel: The flexplate (automatic transmission) or flywheel (manual transmission) bolted to the engine will differ between the 2.2L and 5.3L engines. The bolt pattern, diameter, and possibly even the number of bolts will be incompatible.
* Wiring Harness & Computer: The transmission's wiring harness and its integration with the vehicle's computer system may be different, requiring significant modification or replacement.
* Other Mounting Differences: While the general configuration of the 4L60E is similar, minor mounting bracket differences could exist, impacting installation.
In short, while it's the same *transmission type*, the internal components and associated parts are not interchangeable due to the massive difference in engine output. You would need a 4L60E specifically designed for the 5.3L engine, or at the very least, a complete overhaul of the S10 transmission to adapt it, which would often be more expensive than just sourcing the correct transmission.
