Can a 3.8 liter Pontiac engine fit in 1988 s10 blazer?

No, a 3.8L Pontiac engine (like those found in Grand Prixs and other GM vehicles) will not easily fit in a 1988 S10 Blazer. The S10's engine bay is considerably smaller than what's needed to accommodate a V6 of that size. While some modifications *might* be possible, it would require extensive fabrication, custom mounts, and likely modifications to the firewall, body, and potentially the suspension. It's not a straightforward swap.