While some very basic fasteners or extremely generic parts *might* be similar, you'll find virtually no interchangeability between major components like:
* Cylinder heads: Completely different designs.
* Camshafts: Different profiles and placement.
* Valve train: Rocker arms, pushrods, lifters – all incompatible.
* Intake and exhaust manifolds: Different port locations and configurations.
* Internal components (pistons, connecting rods, crankshaft): While the overall displacement might be the same, internal dimensions will vary.
In short, don't even try to use parts from the Mustang 4.6L SOHC engine on an F-150 4.6L OHV engine without extensive verification. You'll likely cause damage.