* Configuration: The cab style (regular, crew cab), bed length, drivetrain (2WD vs. 4WD), and optional equipment all affect fuel economy. Heavier configurations get worse mileage.
* Driving style: Aggressive acceleration and heavy towing drastically reduce fuel economy.
* Terrain: Driving in mountainous areas or off-road will lower MPG.
* Maintenance: Proper maintenance is crucial for optimal fuel efficiency.
Generally, expect to see EPA estimates in the range of 17-22 mpg on the highway and significantly lower in city driving (often in the low teens or even single digits, especially with a heavy load or when towing).
You will almost certainly *not* achieve the higher end of this range in real-world driving, especially if you frequently tow heavy loads or drive in stop-and-go traffic. Many owners report significantly lower figures than the EPA estimates.
To get a more precise idea, it's best to consult the EPA's FuelEconomy.gov website and search for the specific year and configuration of the Dodge Ram 2500 you're interested in. You can also check online forums and owner reviews for real-world fuel economy reports from other drivers.
