* Cummins ISX15: This 15-liter inline-six engine produces up to 500 horsepower and 1,850 lb-ft of torque. It is available in both single and twin-turbo configurations.
* Detroit DD15: This 15-liter inline-six engine produces up to 505 horsepower and 1,850 lb-ft of torque. It is available in both single and twin-turbo configurations.
* Paccar MX-13: This 12.9-liter inline-six engine produces up to 510 horsepower and 1,850 lb-ft of torque. It is available in both single and twin-turbo configurations.
* Volvo D13: This 13-liter inline-six engine produces up to 500 horsepower and 1,850 lb-ft of torque. It is available in both single and twin-turbo configurations.
The Cascadia is also available with a natural gas-powered engine, the Cummins Westport ISX12N. This 12-liter inline-six engine produces up to 400 horsepower and 1,450 lb-ft of torque.
All of the engines available in the Cascadia are EPA 2010-compliant.