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Will a 78 350 motor bolt to 91 HM290 transmission?

No, a 78 350 motor will not bolt to a 91 HM290 transmission. The 78 350 motor is a small block Chevrolet engine, while the 91 HM290 transmission is a transmission for a GM truck with the 4.3L V6 engine. The bell housing patterns for these two components are different, so they cannot be bolted together.