* Body Style Variations: Even within the same year, there can be subtle differences in body mounts and sheet metal between 1500 and 2500 series trucks. The 2500 is a heavier-duty truck and has a different frame.
* Grill and Headlight Variations: The grilles and headlight assemblies are different between Chevy and GMC, and even between 1500 and 2500 series.
* Frame Differences: The 2500's heavier-duty frame will likely have different mounting points and dimensions compared to the 1500. This is a major obstacle.
You might be able to *adapt* some parts, but a direct bolt-on swap is highly unlikely and would require significant modification, likely making it more trouble than it's worth.