Here's what you need to check:
* Speed-Sensitive Locking: This is the most common type of auto-locking. The doors lock automatically when the vehicle reaches a certain speed. You can't disable this through a simple setting. The only way to prevent this is to manually unlock the doors after reaching that speed, or by disconnecting the relevant wiring (not recommended, as this is complex and can lead to other issues).
* Time-Delay Locking: Some Durangos might lock the doors a few seconds after the vehicle comes to a complete stop and the driver's door is opened. This is also usually not adjustable. Again, manual unlocking is the workaround.
* Alarm System: If you have an aftermarket alarm system installed, its settings may be controlling the auto-locking feature. Check its manual or the installer for adjustment options.
* Dealer Options: Some features varied by factory options. Your Durango's build sheet or the owner's manual *might* offer clues about adjustable settings (though it's unlikely for this specific feature).
In short: There isn't a simple button or menu option to turn off auto-locking on a 2000 Dodge Durango. The most practical solution is to manually unlock the doors if they lock automatically. Any attempt to disable it by messing with wiring should only be done by a qualified mechanic to avoid damaging the vehicle's electrical system.