However, I can tell you that the 2000 Lexus ES 300 does have an interference engine. This means that if the timing belt breaks, the valves can collide with the pistons, causing significant damage to the engine. It's important to ensure the timing belt is in good condition and replaced at the recommended intervals.
If you have a 2000 Lexus ES 300, you should consult your owner's manual or a certified mechanic for the recommended timing belt replacement interval.