* Engine Management: The 88 Blazer's computer and wiring harness are designed for the TBI system. A carbureted engine has no computer control. You'd need a completely new harness, possibly a custom one, and you'd lose all the features related to the TBI system (like O2 sensor feedback for emissions and fuel efficiency).
* Fuel System: The TBI system uses a fuel pump and injectors controlled by the computer. A carbureted engine requires a different fuel pump, fuel lines, and a carburetor.
* Emission Controls: The 88 Blazer likely has emission controls that are incompatible with a carbureted engine. Meeting modern emissions standards with a carbureted setup would be extremely difficult, if not impossible, depending on your location.
* Other Components: There might be other compatibility issues with the transmission, exhaust system, and various other accessories.
While technically *possible* with a lot of custom fabrication, it's a very complex and expensive project far beyond a simple swap. It would be significantly easier and more cost-effective to use a later-model TBI 350 or even a crate engine designed for that era of Blazer.