Will the disc brake set off of a late model s10 truck work on 65 Chevy truck?

No, a disc brake setup from a late-model S10 will almost certainly not work on a 1965 Chevy truck without significant modification, and likely not even then in a practical way. The differences are too substantial:

* Spindle and Hub: The S10 uses a completely different spindle and hub assembly. These are the critical parts that the brakes attach to. They're not interchangeable.

* Mounting Points: The mounting points for the calipers and brake brackets are unique to each vehicle's design. There's no commonality.

* Brake Caliper: The calipers themselves are different sizes and designs.

* Rotor Size and Configuration: The rotor size and bolt pattern are different.

* Backing Plates: The backing plates that hold the brake system components are unique to each truck.

While you *might* be able to fabricate adapters and modify parts, the amount of work involved would be extensive, time-consuming, and likely more expensive than simply buying a disc brake conversion kit specifically designed for a 1965 Chevy truck. Those kits are readily available and designed for a proper, safe installation. Trying to adapt S10 parts would be a risky and likely unsatisfactory endeavor.