To be sure, you should:
* Check the part numbers: Find the part number on the radiator from the 1999 Malibu and compare it to the part number for a 2000 Malibu LS radiator. You can find these numbers on the radiator itself or via online parts catalogs using the VIN of each vehicle.
* Consult a parts catalog: Use an online auto parts website (like AutoZone, Advance Auto Parts, etc.) and enter the year, make, and model of both vehicles. Compare the listed radiators. If the same radiator is listed for both years, it's a strong indication of compatibility.
While seemingly similar, subtle differences *could* exist, especially if the 2000 model had engine or cooling system updates. Taking the extra steps to verify the part numbers is the safest approach.