The thermostat on a 2000 Chevrolet Blazer is located
on the engine, typically under the intake manifold. To be precise, you'll need to consult a repair manual specific to your Blazer's engine (e.g., 4.3L V6, 5.7L V8). The location can vary slightly depending on the engine type.
Accessing it often requires removing parts of the intake manifold or other components for good visibility and access. This is not a simple job and usually requires mechanical knowledge and tools.