* Engine Mounts: The LS3 might require different engine mounts or modification to existing ones to fit properly.
* Wiring Harness: The wiring harness from the LS3 might not be directly compatible with the C5's system, requiring modification or a custom harness.
* Exhaust System: The exhaust system will likely need modification or replacement to accommodate the LS3.
* Accessory Drive: The accessory drive components (alternator, power steering pump, etc.) may require adjustments or replacements due to differences in placement or mounting points.
* Transmission: While the transmission itself *might* be compatible depending on what transmission is already in the C5, the bellhousing might need adaptation or replacement.
In short, while feasible, it's not a simple swap. It's a project that requires mechanical knowledge and expertise, potentially necessitating professional help or significant research and planning.