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Can you flash E350 pcm with program for F-series truck?

No, you cannot directly flash an E350 PCM (Powertrain Control Module) with a program intended for an F-series truck. These vehicles use different PCMs with different firmware, hardware, and calibration strategies. Attempting to do so will almost certainly brick the PCM (render it unusable), requiring replacement.

The E350 and F-series trucks, while both Ford products, have different engine architectures, transmission types, and overall vehicle configurations. Their respective PCMs are tailored to those specific systems. Using incompatible programming will lead to critical system failures and potential damage to other vehicle components.

Always use programming tools and software specifically designed for the vehicle's year, make, model, and engine type. If you're attempting to modify or repair the PCM, ensure you have the correct tools and knowledge, or consult a qualified professional.

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