* F-150's Year and Model: The towing capacity and drivetrain of the F-150 significantly impact whether it can be towed. Older models might be easier to tow than newer ones with complex electronics. Some models require specific towing methods (e.g., flat towing, dolly, or tow dolly). Consult your F-150's owner's manual for its recommended towing procedure, if any. Many newer models require a specialized "tow mode" to be engaged, or flat towing is impossible altogether.
* Motorhome's Towing Capacity: Your motorhome must have enough towing capacity to handle the weight of the F-150. This includes the truck's curb weight plus any added cargo. Check your motorhome's owner's manual for its maximum towing capacity.
* Towing Method: Flat towing (all four wheels on the ground), using a dolly (front or rear wheels lifted), or a full trailer are all options, but each has specific compatibility issues with the F-150's drivetrain and electronics. Flat towing is generally preferred for ease and efficiency, but the F-150's compatibility is highly dependent on the year and model.
* Brake System: When towing a vehicle, you'll likely need a supplemental braking system to help control the F-150 during braking. This is a safety requirement and may be mandated by law.
In short: Before attempting to tow a Ford F-150 behind a motorhome, consult the owner's manuals for both the F-150 and the motorhome. You should also consult with a professional towing expert or RV dealership. Improper towing can cause damage to your vehicles and create a serious safety hazard.