* Automatic Transmission: If it has an automatic transmission, it likely uses Dexron III transmission fluid. However, Dexron VI is also compatible and often recommended as a superior, longer-lasting fluid. Always check your owner's manual for the manufacturer's specific recommendation.
* Manual Transmission: If it has a manual transmission, it uses gear oil. The specific weight of the gear oil (e.g., 75W-90, 80W-90) will be specified in your owner's manual. Using the incorrect weight can damage your transmission.
Crucially: Check your owner's manual. This is the only definitive source for the correct transmission fluid for your specific 2000 Chevy S10. The information above is general and may not apply to your particular truck.