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What is the Model of 2001 2500 HD 4x4 automatic transmission?

The 2001 Chevrolet Silverado 2500 HD 4x4 came with either the 4L80-E or the 4L60-E automatic transmission, depending on the engine and options selected. The 4L80-E was more common in the heavier-duty configurations. To know for certain which transmission is in a specific truck, you'd need to check the vehicle's identification number (VIN) or look at the transmission itself.