Will a Chevy s-10 front end fit 1998 Isuzu hombre?

No, a Chevy S-10 front end will not fit a 1998 Isuzu Hombre. While the Hombre is essentially a rebadged S-10, there are subtle differences, particularly in the bodywork around the front end, that prevent direct interchangeability. The fenders, hood, grille, and bumper are all unique to the Hombre.