* 8.5" 10-bolt: The drain plug is usually located on the bottom of the differential cover, towards the passenger side.
* 7.5" 10-bolt: Similar to the 8.5", the drain plug is generally on the bottom of the differential cover, towards the passenger side.
To be absolutely certain:
1. Locate the differential: It's the housing in the center of the rear axle. It's a large, somewhat cylindrical unit.
2. Look closely at the bottom of the differential cover: The drain plug is usually a large bolt, often slightly recessed. It might be magnetic.
3. Consult a repair manual: A repair manual specific to your 2000 Chevy S10 (including the engine and axle specifics) will give you a precise diagram and instructions. This is the most reliable method.
Before you start, remember to have the correct size drain plug wrench and a drain pan ready to catch the old fluid. Also, be prepared to replace the drain plug gasket or washer.