However, generally, for a 2007 Ford E-350 van, if it's a standard rear axle (not a limited slip), you'll likely need:
* 75W-140 GL-5 gear oil. This is a common specification for heavy-duty applications.
Crucially, if your E-350 has a limited-slip differential (LSD), you will need a specific limited-slip differential fluid. Using the wrong fluid can damage the limited-slip mechanism. The doorjamb sticker or owner's manual will clearly indicate if you have an LSD and specify the correct fluid.
Do not rely solely on this information. Check your vehicle's documentation for the precise specification. Using the incorrect fluid can severely damage your rear differential.