To know for sure, you need to:
1. Check your existing radio opening: Look at the size of the opening in your dash where the factory radio is (or was). Measure the width and height. A double-DIN opening is significantly larger than a single-DIN.
2. Search online for "2000 Chevy Silverado 1500 double DIN dash kit": If you find dash kits specifically for double-DIN radios, it's highly likely it will fit. The absence of readily available kits suggests a single-DIN setup.
3. Look at pictures of 2000 Silverado 1500 interiors online: Compare the dash opening in the pictures to your truck's.
In short, there's no guaranteed yes or no answer without checking your truck directly. The dash kit is crucial – you'll likely need one to install a double-DIN stereo even if the opening *seems* large enough.