The 1999 Ford F-250 V-10 engine (a Triton 6.8L) typically uses
Autolite XP5124 spark plugs. However, it's always best to double-check your owner's manual for the manufacturer's recommended spark plug type and gap specifications. The owner's manual will provide the definitive answer.
While Autolite XP5124 is a common and frequently recommended replacement, other equivalent plugs from different manufacturers might also be suitable, but again, refer to your owner's manual for certainty. Using the wrong type of spark plug can damage your engine.