The gas mileage of a 2006 Pontiac G6 varies depending on the engine and transmission. There wasn't just one engine option. You'll need to specify which engine your G6 has to get an accurate answer. Generally, expect somewhere in the range of
18-28 mpg combined (city and highway). However, this is just an estimate, and your actual mileage will depend on driving habits and vehicle condition.
To find the exact MPG for *your* 2006 Pontiac G6, check the sticker on the driver's side doorjamb or consult the owner's manual. The EPA estimates will be listed there.