While there's no specific mileage interval for replacing a timing chain in a 1994 Astro van like there is for a belt, it's typically considered a very long-life item, often lasting the lifespan of the engine (200,000 miles or more). However, it's advisable to have it inspected during major engine service or if you notice any unusual noises from the engine. A mechanic can assess its condition during a routine inspection.