Will a 2000 2.2 Chevy S-10 engine fit in 1998 S-10?

Yes, a 2000 2.2L Chevy S-10 engine should fit into a 1998 S-10. Both years used the same basic engine bay design and the 2.2L engine remained largely unchanged during that period. However, there might be some minor differences in components (sensors, wiring harnesses, etc.) that could require some adaptation during the swap. You'll likely need to use the wiring harness and computer from the 2000 model to ensure everything works correctly.