1. Battery and Electrical System:
* Dead Battery: This is the most common cause. Check the battery voltage with a voltmeter. It should read around 12.6 volts when fully charged. If it's significantly lower, the battery needs charging or replacing.
* Loose or Corroded Battery Terminals: Clean the terminals with a wire brush and baking soda solution. Make sure they are securely connected.
* Faulty Starter: The starter motor cranks the engine. A clicking sound when you turn the key often indicates a bad starter, low battery, or bad connection.
* Alternator: If the battery is consistently low, the alternator might not be charging it properly.
* Fuses and Relays: Check the fuses and relays related to the ignition system. A blown fuse or bad relay can prevent the starter from engaging.
* Wiring Issues: Damaged or corroded wiring in the ignition system can interrupt the electrical flow.
2. Fuel System:
* Empty Fuel Tank: Sounds obvious, but check the fuel gauge.
* Fuel Pump: A malfunctioning fuel pump won't deliver fuel to the engine. You might hear a humming sound from the pump when you turn the key if it's working, but weak.
* Fuel Filter: A clogged fuel filter restricts fuel flow.
* Fuel Injectors: Clogged or malfunctioning fuel injectors prevent fuel from reaching the engine's cylinders.
3. Ignition System:
* Ignition Switch: A faulty ignition switch prevents power from reaching the starter and other components.
* Ignition Coil: The ignition coil provides the high voltage needed to spark the plugs. A bad coil will prevent the engine from firing.
* Spark Plugs and Wires: Worn or fouled spark plugs or damaged spark plug wires can prevent combustion.
* Distributor (if applicable): Older S-10s might have distributors; a faulty distributor cap, rotor, or ignition module can cause starting problems.
* Crankshaft Position Sensor (CKP): This sensor tells the computer the position of the crankshaft. A faulty CKP sensor prevents the engine from starting.
4. Engine Mechanical Issues (Less Likely to Prevent ALL Starting):
* Timing Belt/Chain: A broken timing belt or chain will prevent the engine from running, but you might still hear the starter crank the engine.
* Seized Engine: In rare cases, the engine might be seized due to lack of lubrication.
Troubleshooting Steps:
1. Check the battery voltage.
2. Listen for sounds: A clicking sound might indicate a starter issue. A whirring sound might indicate a weak starter motor or low battery. No sound at all could be a battery or ignition problem.
3. Check fuses and relays.
4. Check fuel level.
5. Have the vehicle checked by a mechanic if you can't find the problem.
Without more information about the symptoms (e.g., does the engine crank? Are there any sounds? Does the fuel gauge show a reading?), it's impossible to pinpoint the exact cause. Provide more details to get a more specific answer.