* Mounting: The engine mounts are different between the Mustang and the F-150. You'll need to fabricate or source new motor mounts to fit the Mustang engine into the F-150's engine bay.
* Transmission: The transmissions are likely different. You'll need to consider the transmission compatibility. You might need to adapt the transmission from the Mustang to your F-150, or use the F-150's transmission with modifications. This could be a major undertaking.
* Wiring Harness: The wiring harnesses are completely different. You'll need to either modify the Mustang harness extensively to work with the F-150's system or use a stand-alone engine management system.
* Exhaust: The exhaust manifolds/headers will likely need modification or replacement to fit the F-150's frame.
* Fuel System: While both are fuel-injected 302s, the fuel systems might be different enough to require adaptation or replacement.
* Accessories: The placement of accessories (alternator, power steering pump, etc.) might differ, requiring adjustments or replacements.
In short, while the engine *could* physically fit with enough fabrication, the project would be extensive, requiring significant mechanical knowledge, welding skills, and possibly custom parts. It's not a simple bolt-in swap. It's far more practical to consider a direct replacement 302 from a similar-year F-150.